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Receptor

Search Result - 1

HMRbase accession number	20222
Swiss-prot Accession number	Q6VB83 (Sequence in FASTA format)
Description	Serotonin receptor.
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (By similarity).
Protein Length	365 Amino acids
Molecular weight	41653
Domain Name	7tm_1
References	1  PubMed abstract 14744596
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 2

HMRbase accession number	20298
Swiss-prot Accession number	O08892 (Sequence in FASTA format)
Description	5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5-HT1B).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	Phosphorylated (By similarity). Palmitoylated (By similarity).
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Protein Length	389 Amino acids
Molecular weight	43111
Domain Name	7tm_1
References	1  PubMed abstract 9225276
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 3

HMRbase accession number	20311
Swiss-prot Accession number	Q60484 (Sequence in FASTA format)
Description	5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Protein Length	376 Amino acids
Molecular weight	41769
Domain Name	7tm_1
References	1  PubMed abstract 8978753 2  PubMed abstract 9225276
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 4

HMRbase accession number	20318
Swiss-prot Accession number	O08890 (Sequence in FASTA format)
Description	5-hydroxytryptamine 1F receptor (5-HT-1F) (Serotonin receptor 1F) (5-HT1F).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Protein Length	366 Amino acids
Molecular weight	41839
Domain Name	7tm_1
References	1  PubMed abstract 9225282
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 5

HMRbase accession number	20342
Swiss-prot Accession number	O70528 (Sequence in FASTA format)
Description	5-hydroxytryptamine 4 receptor (5-HT-4) (Serotonin receptor 4) (5-HT4).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity).
Protein Length	388 Amino acids
Molecular weight	43726
Domain Name	7tm_1
References	1   Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R.,Leysen J., Luyten W., Bender E.; "Cloning and expression of 5-HT4 receptor species and splicevariants."; Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 6

HMRbase accession number	20354
Swiss-prot Accession number	P50407 (Sequence in FASTA format)
Description	5-hydroxytryptamine 7 receptor (5-HT-7) (Serotonin receptor 7) (5-HT-X).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Protein Length	446 Amino acids
Molecular weight	49614
Domain Name	7tm_1
References	1  PubMed abstract 7518496
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 7

HMRbase accession number	20394
Swiss-prot Accession number	Q6EX43 (Sequence in FASTA format)
Description	5-hydroxytryptamine receptor 5A.
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	356 Amino acids
Molecular weight	40141
Domain Name	7tm_1
References	1  PubMed abstract 15212962
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 8

HMRbase accession number	20745
Swiss-prot Accession number	Q9WU25 (Sequence in FASTA format)
Description	Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins (By similarity).
Protein Length	466 Amino acids
Molecular weight	51578
Domain Name	7tm_1
References	1  PubMed abstract 11527538
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 9

HMRbase accession number	20760
Swiss-prot Accession number	Q60474 (Sequence in FASTA format)
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Protein Length	450 Amino acids
Molecular weight	48911
Domain Name	7tm_1
References	1  PubMed abstract 8573196
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 10

HMRbase accession number	20765
Swiss-prot Accession number	Q60475 (Sequence in FASTA format)
Description	Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2Badrenoreceptor).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Protein Length	448 Amino acids
Molecular weight	49597
Domain Name	7tm_1
References	1  PubMed abstract 8573196
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 11

HMRbase accession number	20769
Swiss-prot Accession number	Q60476 (Sequence in FASTA format)
Description	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2Cadrenoreceptor).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Protein Length	455 Amino acids
Molecular weight	49351
Domain Name	7tm_1
References	1  PubMed abstract 8573196
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 12

HMRbase accession number	20809
Swiss-prot Accession number	Q3HNP5 (Sequence in FASTA format)
Description	Beta 3-adrenoceptor.
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis (By similarity).
Protein Length	379 Amino acids
Molecular weight	40324
Domain Name	N/A
References	1   Lau Y.M., Au L.S., Seto S.W., Kwan Y.W., Tsui K.W., Liu W.K.; "Nitric oxide-mediated beta 3-adrenoceptor inhibition of basal L-typeCa2+ channels of guinea-pig single ventricular myocyte."; Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 13

HMRbase accession number	20836
Swiss-prot Accession number	Q8K4Z4 (Sequence in FASTA format)
Description	Beta2-adrenergic receptor.
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
Protein Length	418 Amino acids
Molecular weight	46991
Domain Name	7tm_1
References	1  PubMed abstract 12460637
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 14

HMRbase accession number	20950
Swiss-prot Accession number	O08893 (Sequence in FASTA format)
Description	Calcitonin receptor precursor (CT-R).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 2 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Protein Length	478 Amino acids
Molecular weight	55554
Domain Name	7tm_2  HRM
References	1  PubMed abstract 9231703 2  PubMed abstract 9231703
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 15

HMRbase accession number	20955
Swiss-prot Accession number	Q63931 (Sequence in FASTA format)
Description	Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
Protein Length	430 Amino acids
Molecular weight	48211
Domain Name	N/A
References	1  PubMed abstract 7916580 2  PubMed abstract 7916580
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 16

HMRbase accession number	21141
Swiss-prot Accession number	Q8CH60 (Sequence in FASTA format)
Description	Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Protein Length	328 Amino acids
Molecular weight	37690
Domain Name	7tm_1
References	1   Fujii Y., Ikemoto T., Park M.K.; "Molecular cloning of a GnRH receptor in the guinea pig."; Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Hormone	O54713   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 17

HMRbase accession number	21154
Swiss-prot Accession number	Q8R428 (Sequence in FASTA format)
Description	Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats.
Tissue Specificity	N/A
Post translational modification	N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity).
Function	Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).
Protein Length	695 Amino acids
Molecular weight	77838
Domain Name	N/A
References	1  PubMed abstract 12506355 2  PubMed abstract 12506355
Hormone	Q9JK68   Detail in HMRbase    Q9JK69   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 18

HMRbase accession number	21191
Swiss-prot Accession number	Q9JI97 (Sequence in FASTA format)
Description	Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)].
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cell membrane; single-pass type I membrane protein (By similarity). Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.
Tissue Specificity	N/A
Post translational modification	On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
Function	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling (By similarity).
Protein Length	628 Amino acids
Molecular weight	70355
Domain Name	N/A
References	1  PubMed abstract 12110920 2  PubMed abstract 10767558 3   Jullie H.A., Ymer S.I., Harrop S.A., Odorico D.M., Herington A.C.; "Sequence of the guinea pig growth hormone (GH) receptor: a possibleexplanation for the GH insensitivity of the guinea pig."; Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Hormone	Q9JKM4   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 19

HMRbase accession number	21204
Swiss-prot Accession number	Q9Z1S9 (Sequence in FASTA format)
Description	Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R)(Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor).
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Membrane; multi-pass membrane protein
Developmental Stage	N/A
Similarity	Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.
Protein Length	297 Amino acids
Molecular weight	33715
Domain Name	7tm_1
References	1   Fang V.S., Juan C.-C., Lin Y.-S., Liu S.-T., Ho L.-T.; "Cloning of the guinea pig corticotropin (ACTH)-receptor gene."; Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. 2   Fang V.S., Juan C.-C., Lin Y.-S., Liu S.-T., Ho L.-T.; "Cloning of the guinea pig corticotropin (ACTH)-receptor gene."; Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Hormone	P19402   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 20

HMRbase accession number	21298
Swiss-prot Accession number	P49115 (Sequence in FASTA format)
Description	RecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1;
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	Increased proteasome-mediated degradation in response to glucocorticoids (By similarity). Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). Sumoylated; this reduces transcription transactivation (By similarity).
Function	Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
Protein Length	771 Amino acids
Molecular weight	84862
Domain Name	GCR  Hormone_recep  zf-C4
References	1  PubMed abstract 8052264
Hormone	Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 21

HMRbase accession number	21417
Swiss-prot Accession number	O35507 (Sequence in FASTA format)
Description	Peroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group C member 1
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	Nucleus
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids (By similarity).
Protein Length	467 Amino acids
Molecular weight	52313
Domain Name	Hormone_recep  zf-C4
References	1  PubMed abstract 9520140
Hormone	Detail in HMRbase    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 22

HMRbase accession number	21882
Swiss-prot Accession number	O70527 (Sequence in FASTA format)
Description	Peroxisome proliferator activated receptor alpha; Fragment
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	467 Amino acids
Molecular weight	52285
Domain Name	Hormone_recep  zf-C4
References	1  PubMed abstract 9620871
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 23

HMRbase accession number	22329
Swiss-prot Accession number	Q80VX5 (Sequence in FASTA format)
Description	Retinoic acid receptor beta
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	410 Amino acids
Molecular weight	46411
Domain Name	Hormone_recep  zf-C4
References	----
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 24

HMRbase accession number	22424
Swiss-prot Accession number	Q8CGK8 (Sequence in FASTA format)
Description	Estrogen receptor alpha; Fragment
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	353 Amino acids
Molecular weight	40100
Domain Name	Hormone_recep
References	----
Hormone	Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 25

HMRbase accession number	22425
Swiss-prot Accession number	Q8CGK9 (Sequence in FASTA format)
Description	Estrogen receptor 2; Fragment
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	335 Amino acids
Molecular weight	37779
Domain Name	Hormone_recep  zf-C4
References	----
Hormone	Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 26

HMRbase accession number	22693
Swiss-prot Accession number	Q99PC7 (Sequence in FASTA format)
Description	Peroxisome proliferator activated receptor-gamma; Fragment
Source organism	Cavia porcellus (Guinea pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	475 Amino acids
Molecular weight	54426
Domain Name	Hormone_recep  zf-C4
References	1  PubMed abstract 12524031
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated